ChloroquineV1, Main, Exploration, bibRecord, 001023

In vitro and in vivo antischistosomal activity of ferroquine derivatives.

Identifieur interne : 001023 ( Main/Exploration ); précédent : 001022; suivant : 001024

In vitro and in vivo antischistosomal activity of ferroquine derivatives.

Auteurs : Jennifer Keiser [Suisse] ; Mireille Vargas ; Riccardo Rubbiani ; Gilles Gasser ; Christophe Biot

Source :

Parasites & vectors [ 1756-3305 ] ; 2014.

RBID : pubmed:25190030

Descripteurs français

KwdFr :
- Aminoquinoléines (), Aminoquinoléines (pharmacologie), Animaux, Cellules HeLa, Composés du fer II (), Composés du fer II (pharmacologie), Femelle, Humains, Schistosoma mansoni (), Schistosomiase à Schistosoma mansoni (traitement médicamenteux), Schistosomicides (pharmacologie), Souris, Structure moléculaire.
MESH :
- pharmacologie : Aminoquinoléines, Composés du fer II, Schistosomicides.
- traitement médicamenteux : Schistosomiase à Schistosoma mansoni.
- Aminoquinoléines, Animaux, Cellules HeLa, Composés du fer II, Femelle, Humains, Schistosoma mansoni, Souris, Structure moléculaire.

English descriptors

KwdEn :
- Aminoquinolines (chemistry), Aminoquinolines (pharmacology), Animals, Female, Ferrous Compounds (chemistry), Ferrous Compounds (pharmacology), HeLa Cells, Humans, Metallocenes, Mice, Molecular Structure, Schistosoma mansoni (drug effects), Schistosomiasis mansoni (drug therapy), Schistosomicides (pharmacology).
MESH :
- chemical , chemistry : Aminoquinolines, Ferrous Compounds.
- chemical , pharmacology : Aminoquinolines, Ferrous Compounds, Schistosomicides.
- drug effects : Schistosoma mansoni.
- drug therapy : Schistosomiasis mansoni.
- Animals, Female, HeLa Cells, Humans, Metallocenes, Mice, Molecular Structure.

Abstract

Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. The aim of the present work was to study the antischistosomal activity of ferroquine against Schistosoma mansoni adult worms and newly transformed schistosomula (NTS) in vitro and in vivo. Hydroxyl-ferroquine and ruthenoquine were included to study the potential role of reactive oxygen species in the antischistosomal activity. Chloroquine and mefloquine, the later described for its antischistosomal properties, served as comparators.

DOI: 10.1186/1756-3305-7-424
PubMed: 25190030

Affiliations:

Suisse

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vitro and in vivo antischistosomal activity of ferroquine derivatives.</title>
<author><name sortKey="Keiser, Jennifer" sort="Keiser, Jennifer" uniqKey="Keiser J" first="Jennifer" last="Keiser">Jennifer Keiser</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland. jennifer.keiser@unibas.ch.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vargas, Mireille" sort="Vargas, Mireille" uniqKey="Vargas M" first="Mireille" last="Vargas">Mireille Vargas</name>
</author>
<author><name sortKey="Rubbiani, Riccardo" sort="Rubbiani, Riccardo" uniqKey="Rubbiani R" first="Riccardo" last="Rubbiani">Riccardo Rubbiani</name>
</author>
<author><name sortKey="Gasser, Gilles" sort="Gasser, Gilles" uniqKey="Gasser G" first="Gilles" last="Gasser">Gilles Gasser</name>
</author>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:25190030</idno>
<idno type="pmid">25190030</idno>
<idno type="doi">10.1186/1756-3305-7-424</idno>
<idno type="wicri:Area/PubMed/Corpus">000283</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000283</idno>
<idno type="wicri:Area/PubMed/Curation">000283</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000283</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000292</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000292</idno>
<idno type="wicri:Area/Ncbi/Merge">000261</idno>
<idno type="wicri:Area/Ncbi/Curation">000261</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000261</idno>
<idno type="wicri:Area/Main/Merge">001024</idno>
<idno type="wicri:Area/Main/Curation">001023</idno>
<idno type="wicri:Area/Main/Exploration">001023</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">In vitro and in vivo antischistosomal activity of ferroquine derivatives.</title>
<author><name sortKey="Keiser, Jennifer" sort="Keiser, Jennifer" uniqKey="Keiser J" first="Jennifer" last="Keiser">Jennifer Keiser</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland. jennifer.keiser@unibas.ch.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vargas, Mireille" sort="Vargas, Mireille" uniqKey="Vargas M" first="Mireille" last="Vargas">Mireille Vargas</name>
</author>
<author><name sortKey="Rubbiani, Riccardo" sort="Rubbiani, Riccardo" uniqKey="Rubbiani R" first="Riccardo" last="Rubbiani">Riccardo Rubbiani</name>
</author>
<author><name sortKey="Gasser, Gilles" sort="Gasser, Gilles" uniqKey="Gasser G" first="Gilles" last="Gasser">Gilles Gasser</name>
</author>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
</author>
</analytic>
<series><title level="j">Parasites & vectors</title>
<idno type="eISSN">1756-3305</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoquinolines (chemistry)</term>
<term>Aminoquinolines (pharmacology)</term>
<term>Animals</term>
<term>Female</term>
<term>Ferrous Compounds (chemistry)</term>
<term>Ferrous Compounds (pharmacology)</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Metallocenes</term>
<term>Mice</term>
<term>Molecular Structure</term>
<term>Schistosoma mansoni (drug effects)</term>
<term>Schistosomiasis mansoni (drug therapy)</term>
<term>Schistosomicides (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aminoquinoléines ()</term>
<term>Aminoquinoléines (pharmacologie)</term>
<term>Animaux</term>
<term>Cellules HeLa</term>
<term>Composés du fer II ()</term>
<term>Composés du fer II (pharmacologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Schistosoma mansoni ()</term>
<term>Schistosomiase à Schistosoma mansoni (traitement médicamenteux)</term>
<term>Schistosomicides (pharmacologie)</term>
<term>Souris</term>
<term>Structure moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Aminoquinolines</term>
<term>Ferrous Compounds</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminoquinolines</term>
<term>Ferrous Compounds</term>
<term>Schistosomicides</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Schistosoma mansoni</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Schistosomiasis mansoni</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminoquinoléines</term>
<term>Composés du fer II</term>
<term>Schistosomicides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Schistosomiase à Schistosoma mansoni</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Metallocenes</term>
<term>Mice</term>
<term>Molecular Structure</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aminoquinoléines</term>
<term>Animaux</term>
<term>Cellules HeLa</term>
<term>Composés du fer II</term>
<term>Femelle</term>
<term>Humains</term>
<term>Schistosoma mansoni</term>
<term>Souris</term>
<term>Structure moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. The aim of the present work was to study the antischistosomal activity of ferroquine against Schistosoma mansoni adult worms and newly transformed schistosomula (NTS) in vitro and in vivo. Hydroxyl-ferroquine and ruthenoquine were included to study the potential role of reactive oxygen species in the antischistosomal activity. Chloroquine and mefloquine, the later described for its antischistosomal properties, served as comparators.</div>
</front>
</TEI>
<affiliations><list><country><li>Suisse</li>
</country>
</list>
<tree><noCountry><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<name sortKey="Gasser, Gilles" sort="Gasser, Gilles" uniqKey="Gasser G" first="Gilles" last="Gasser">Gilles Gasser</name>
<name sortKey="Rubbiani, Riccardo" sort="Rubbiani, Riccardo" uniqKey="Rubbiani R" first="Riccardo" last="Rubbiani">Riccardo Rubbiani</name>
<name sortKey="Vargas, Mireille" sort="Vargas, Mireille" uniqKey="Vargas M" first="Mireille" last="Vargas">Mireille Vargas</name>
</noCountry>
<country name="Suisse"><noRegion><name sortKey="Keiser, Jennifer" sort="Keiser, Jennifer" uniqKey="Keiser J" first="Jennifer" last="Keiser">Jennifer Keiser</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001023 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001023 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25190030
   |texte=   In vitro and in vivo antischistosomal activity of ferroquine derivatives.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25190030" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

In vitro and in vivo antischistosomal activity of ferroquine derivatives.

In vitro and in vivo antischistosomal activity of ferroquine derivatives.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.